Self-Assembled Nanoflowers from Natural Building Blocks with Antioxidant, Antibacterial, and Antibiofilm Properties

Polyphenols, natural compounds abundant in phenolic structures, have received widespread attention due to their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them valuable for biomedical applications. However, the green synthesis of polyphenol-based materials with economical and environmentally friendly strategies is of great significance. In this study, a multifunctional wound dressing was achieved by introducing polyphenol-based materials of copper phosphate-tannic acid with a flower-like structure (Cu-TA NFs), which show the reactive oxygen species scavenging performance. This strategy endowed the electrospun wound dressing, composed of poly(caprolactone)-coated gum arabic-poly(vinyl alcohol) nanofibers (GPP), with the antibacterial and antibiofilm properties. Our research demonstrates that GPP/Cu-TA NFs are effective against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Furthermore, the developed GPP/Cu-TA NFs showed excellent hemocompatibility and biocompatibility. These results suggest that the synergistic properties of this multifunctional polyphenol platform (GPP/Cu-TA NFs) make it a promising candidate for the further development of wound dressing materials.