Navigating coagulopathy in obstetric hemorrhage: The role of point-of-care testing

Nicholas Gill; Alexander Butwick; Sarah F Bell

doi:10.1016/j.bpa.2024.10.002

Navigating coagulopathy in obstetric hemorrhage: The role of point-of-care testing

Best Pract Res Clin Anaesthesiol. 2024 Sep;38(3):233-245. doi: 10.1016/j.bpa.2024.10.002. Epub 2024 Oct 9.

Authors

Nicholas Gill¹, Alexander Butwick², Sarah F Bell³

Affiliations

¹ Department of Anaesthesia and Perioperative Medicine, Cardiff and Vale University Hospital, Cardiff, UK. Electronic address: [email protected].
² Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
³ Department of Anaesthesia and Perioperative Medicine, Cardiff and Vale University Hospital, Cardiff, UK.

PMID: 39764813
DOI: 10.1016/j.bpa.2024.10.002

Abstract

Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality and morbidity worldwide. Recent advances in understanding the hemostatic changes of pregnancy and PPH have led to the development of obstetric-specific approaches to resuscitation. This article aims to examine. 1) changes in the coagulation system during pregnancy. 2) types of coagulopathy associated with PPH, and. 3) the role of point of care tests of coagulation in PPH.

Keywords: Fibrinogen concentrate; Obstetric coagulopathy; Postpartum hemorrhage; Tranexamic acid; Viscoelastic hemostatic assays.

Publication types

Review

MeSH terms

Blood Coagulation Disorders* / blood
Blood Coagulation Disorders* / diagnosis
Blood Coagulation Disorders* / etiology
Blood Coagulation Disorders* / therapy
Female
Humans
Point-of-Care Testing*
Postpartum Hemorrhage* / blood
Postpartum Hemorrhage* / diagnosis
Postpartum Hemorrhage* / therapy
Pregnancy