Direct Synthesis of 2-Functionalized 3-Nitroindoles from Diazo(nitro)acetanilides

J Org Chem. 2025 Jan 7. doi: 10.1021/acs.joc.4c02622. Online ahead of print.

Abstract

2-Hydroxyl/acetoxy-3-nitroindoles are directly and efficiently prepared in good to excellent yields from diazo(nitro)acetanilides under the catalysis of Cu(MeCN)4PF6 in DCM through an intramolecular aromatic C-H insertion or followed by acetylation. 2-Hydroxyl-3-nitroindoles can be further transformed to 3-halo-3-nitroindolin-2-ones and 3-alkanamidoindolin-2-ones readily. All of them are important synthetic building blocks for construction of indole derivatives.