Acanthosis nigricans-like hyperpigmentation secondary to triazinate therapy

Arch Dermatol. 1985 Feb;121(2):232-5.

Abstract

Cutaneous hyperpigmentation resembling acanthosis nigricans developed in two patients with malignant brain tumors following chemotherapy with triazinate (Baker's Antifol), a folic acid antagonist. In both cases, the eruption resolved after the cessation of drug administration and reappeared after the reinstitution of triazinate therapy. A skin biopsy specimen from one patient showed microscopic changes consistent with those found in acanthosis nigricans. The other patient had a decreased serum folate level that returned to normal as the hyperpigmentation resolved. Folate may have a role in triazinate-induced acanthosislike hyperpigmentation.

Publication types

  • Case Reports

MeSH terms

  • Acanthosis Nigricans / diagnosis
  • Adult
  • Antineoplastic Agents / adverse effects*
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Pigmentation Disorders / chemically induced*
  • Pigmentation Disorders / diagnosis
  • Pigmentation Disorders / pathology
  • Skin / pathology
  • Triazines / adverse effects*

Substances

  • Antineoplastic Agents
  • Triazines
  • triazinate