Aggressive Infection by K1/ST1265 Klebsiella pneumoniae Leading to Multiple Abscesses: Case Report and Literature Review

Infect Drug Resist. 2025 Jan 3:18:43-49. doi: 10.2147/IDR.S489161. eCollection 2025.

Abstract

Hypervirulent Klebsiella pneumoniae (hvKp) has attracted increasing attention in recent years. Diabetes and serotype K1 or K2 are risk factors for invasive liver abscess syndrome including liver abscesses and the metastatic complications such as bacteremia, meningitis, endophthalmitis, and necrotizing fasciitis. Simultaneous infections of the liver, lungs, prostate, brain, and eyes are exceedingly rare. In this paper, a 41-year-old male patient who presented with a 4-day history of fever with polydipsia and polyuria and untreated diabetes deteriorated dramatically with sepsis, prostate abscess, lung abscess, liver abscess and intracranial infection as well as endophthalmitis. He was diagnosed with infection by K1/ST1265 hypervirulent Klebsiella pneumoniae and after treatment with antibiotics and abscess drainage, while the patient still passed away. K1/ST1265 hvKp exhibits exceptionally high virulence and invasiveness, necessitating broad awareness and vigilant monitoring.

Keywords: Klebsiella pneumoniae; brain abscess; liver abscess; prostate abscess; sequence type 1265; serotype K1.

Publication types

  • Case Reports