Extracorporeal Membrane Oxygenation Use in Pediatric Trauma: A Report From the National Trauma Data Bank

Mahmoud G El Baassiri; Eric Etchill; Charbel Chidiac; Elio R Bitar; Yara Menassa; Alejandro V Garcia; Isam W Nasr

doi:10.1016/j.jpedsurg.2024.162130

Extracorporeal Membrane Oxygenation Use in Pediatric Trauma: A Report From the National Trauma Data Bank

J Pediatr Surg. 2024 Dec 31;60(3):162130. doi: 10.1016/j.jpedsurg.2024.162130. Online ahead of print.

Authors

Mahmoud G El Baassiri¹, Eric Etchill¹, Charbel Chidiac¹, Elio R Bitar¹, Yara Menassa¹, Alejandro V Garcia¹, Isam W Nasr²

Affiliations

¹ Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: [email protected].

PMID: 39778429
DOI: 10.1016/j.jpedsurg.2024.162130

Abstract

Introduction: Indications for extracorporeal membrane oxygenation (ECMO) in pediatric trauma continue to evolve. This study evaluates trends and practices in ECMO use for injured children and identifies factors associated with mortality using the National Trauma Data Bank (NTDB).

Methods: We conducted a retrospective review of children ≤18 years who underwent ECMO therapy following trauma, recorded in the NTDB from 2007 to 2018. The primary outcome was in-hospital mortality. Secondary outcomes were hospital length of stay (LOS) and in-hospital complications. Multivariable regression models identified factors associated with mortality.

Results: Out of 217 children cannulated onto ECMO from 2007 to 2018, 172 (79.2 %) were from 2013 to 2018. Median age was 16 years (IQR 9-17) and 158 (72.8 %) patients were male. The median injury severity score was 26 (IQR 18-38). The thorax (71.9 %) and extremities (63.6 %) were the most common sites injured. Overall, in-hospital mortality was 37.3 %. Median ICU LOS among survivors was 16 days (IQR 5-32). Common complications included acute respiratory failure (29 %), cardiac arrest (24 %) and acute renal failure (17.5 %). On multivariable analysis, higher ISS (adjusted OR [aOR] 1.04, 95%CI 1.01-1.07), the presence of burn injuries (aOR 4.35, 95%CI 1.01-18.74), ICH of unspecified type at presentation (aOR 4.22, 95%CI 1.21-14.68), and intentional injury (aOR 12.7, 95%CI 2.77-58.26) were associated with increased mortality.

Conclusion: This is the largest contemporaneous study of ECMO use in injured children. Many factors such as ISS, cardiac arrest, presence of burn injuries and unspecified ICH increase the rate of in-hospital mortality following ECMO utilization post-trauma. The increase in ECMO utilization over the years support its role as a potentially effective intervention for pediatric trauma patients.

Study type: Original Article (Retrospective study, level of evidence III).

Keywords: ECMO; Outcomes; Pediatric; Trauma.