Divide and conquer, mitochondrial edition: Subpopulations direct cellular energy and nutrient supply

Sijie Tan; Nora Kory

doi:10.1016/j.cmet.2024.12.006

Divide and conquer, mitochondrial edition: Subpopulations direct cellular energy and nutrient supply

Cell Metab. 2025 Jan 7;37(1):5-6. doi: 10.1016/j.cmet.2024.12.006.

Authors

Sijie Tan¹, Nora Kory²

Affiliations

¹ Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
² Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: [email protected].

PMID: 39778519
DOI: 10.1016/j.cmet.2024.12.006

Abstract

Mitochondria produce energy and building blocks essential for cell growth. How these competing processes are balanced and sustained during nutrient scarcity remains unclear. Ryu et al. uncover distinct mitochondrial subpopulations, one dedicated to ATP production and another to macromolecule synthesis, enabling cell growth and proliferation under nutrient-limiting conditions.

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Cell Proliferation
Energy Metabolism*
Humans
Mitochondria* / metabolism
Nutrients* / metabolism

Substances

Adenosine Triphosphate