Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Nature. 2025 Jan;637(8045):E11-E14. doi: 10.1038/s41586-024-07974-0. Epub 2025 Jan 8.

Max L Valenstein^#^{1

2

3

4}, Pranav V Lalgudi^#^{5

6}, Jibril F Kedir^{5

6}, Kendall J Condon^{5

6}, Anna Platzek⁵, Daniel G Freund⁵, Martin S Taylor^{7

8}, Yunhan Xu⁹, Raghu R Chivukula^{10

7

9

11}, David M Sabatini¹²

¹ Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. [email protected].
² Whitehead Institute for Biomedical Research, Cambridge, MA, USA. [email protected].
³ Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected].
⁴ Harvard Medical School, Boston, MA, USA. [email protected].
⁵ Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
⁶ Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁷ Harvard Medical School, Boston, MA, USA.
⁸ Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
⁹ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
¹⁰ Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
¹¹ Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
¹² Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.

^# Contributed equally.

No abstract available

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