Microwave-Assisted Synthesis of Bis-1,2,3-Triazole Based Benzophenones, In Vitro Antimicrobial Activity and Molecular Docking Studies

In this work, we have adopted an easy route to synthesizing bis-1,2,3-triazole-based benzophenone compounds via a 1,3-dipolar cycloaddition reaction (Click Chemistry). All the target compounds achieved better yields though the microwave-assisted method than the conventional method. Target compounds structure were confirmed based on the IR, 1H NMR, 13C NMR and HR Mass analysis. Additionally, we have carried out in vitro antibacterial and antifungal activities with Ciprofloxacin and Fluconazole standard drugs, respectively. The compounds 5b, 5f, 5i, 5k and 5n antibacterial, 5a, 5e, 5g, 5i, and 5k showed promising antifungal activity with respect to standard drugs. Further, molecular docking study performed against DNA gyrase and Lanosterol 14-alpha demethylase envisioned promising binding interactions with a good docking score.