Background: Primary Progressive Aphasia (PPA) is a clinical and symptomatic concept due to neurodegenerative diseases which language symptom was dominant from early clinical stage. PPA is categorized into 3 subtypes such as Progressive non-fluent aphasia (PNFA), Semantic dementia (SD), and logopenic progressive aphasia (LPA). In this study, we compared the differences of PPA subtypes depend on amyloid PET results.
Method: We recruited PPA patients who underwent standard aphasia test (SLTA) as Japanese aphasia test, cerebrospinal fluid AD biomarker, and amyloid PET. We divided into Amyloid PET positive (A(+) PPA) and negative (A(-) PPA) group. then we compared the characterization of SLTA results and CSF biomarker between two groups.
Result: A total of 15 patients were included. There were 7 patients in A (+) PPA groups (2 males and 5 females, age: 65.3±8.3 years), and 8 patients in A (-) PPA group (6 males and 2 females, age: 66.6±11.2 years). Regarding cerebrospinal fluid AD biomarkers, a significant decrease in Aβ42/40 (p < 0.01) and significant elevation in P-tau (p<0.01) was observed in the A (+) PPA group compared to the A (-) PPA group. In SLTA, the A (+) PPA had LPA: 57% and transcortical sensory aphasia: 29%. on the other hand, A (-) PPA group had PNFA: 38% and SD: 50%.
Conclusion: This study showed there is the possibility of SLTA may be useful to predict AD pathology in patients with PPA.
© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.