Mediators of a randomized controlled trial of a preventive intervention for youth of parents with depressive disorders

J Consult Clin Psychol. 2025 Jan;93(1):1-13. doi: 10.1037/ccp0000928.

Abstract

Objective: The present study assessed two theory-driven mediators of the effects of a family group cognitive-behavioral (FGCB) preventive intervention for youth of parents with a history of major depressive disorder (MDD) or dysthymia on long-term youth psychopathology symptoms and diagnoses.

Method: Sample included 180 parents (Mage = 41.9, 89% female, 82% White, non-Hispanic) and one of their children/adolescents ages 9-15 years (Mage = 11.4, 49% female, 74% White, non-Hispanic). Changes in the hypothesized mediators, observations of positive parenting (Iowa Family Interaction Rating Scales) and youth secondary control coping (SCC) skills (Responses to Stress Questionnaire), were assessed at 6 months. Changes in youth psychopathology symptoms were assessed on the Child Behavior Checklist and Youth Self-Report at 18- and 24-month follow-ups and MDD diagnoses with the Kiddie Schedule for Affective Disorders and Schizophrenia at 12 and 24 months.

Results: Changes in youth SCC skills (e.g., acceptance, reappraisal) after the intervention mediated the effects of the FGCB program on changes in youth internalizing and externalizing symptoms at 18- and 24-month follow-ups. Effects for changes in positive parenting behaviors as a mediator were more limited. SCC skills were further shown to mediate the effects of the FGCB intervention on MDD diagnoses from 12 to 24 months.

Conclusions: This study provides clear and strong evidence that changes in youth SCC skills mediated the long-term effects of preventive intervention for families of depressed parents. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Trial registration: ClinicalTrials.gov NCT00183482.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adaptation, Psychological*
  • Adolescent
  • Adult
  • Child
  • Child of Impaired Parents* / psychology
  • Cognitive Behavioral Therapy* / methods
  • Depressive Disorder, Major* / prevention & control
  • Dysthymic Disorder / prevention & control
  • Dysthymic Disorder / psychology
  • Family Therapy / methods
  • Female
  • Humans
  • Male
  • Parent-Child Relations
  • Parenting* / psychology
  • Parents / psychology
  • Psychotherapy, Group / methods

Associated data

  • ClinicalTrials.gov/NCT00183482