Facile fabrication of sensing electrode based on CoFe-MOFs/MXene for ultrasensitive detection of picomolar chloramphenicol

Bowen Shen; Biao Hong; Xinyue Guo; Ruonan Hu; Luodi Wang; Yuchuan Jiang; Wei Li; Wenqing Liu; Zhengyan Wu; Pengqi Yang

doi:10.1016/j.talanta.2025.127552

Facile fabrication of sensing electrode based on CoFe-MOFs/MXene for ultrasensitive detection of picomolar chloramphenicol

Talanta. 2025 Jan 6:286:127552. doi: 10.1016/j.talanta.2025.127552. Online ahead of print.

Authors

Bowen Shen¹, Biao Hong², Xinyue Guo³, Ruonan Hu⁴, Luodi Wang⁴, Yuchuan Jiang⁴, Wei Li¹, Wenqing Liu⁵, Zhengyan Wu⁶, Pengqi Yang⁷

Affiliations

¹ School of Environment Science and Optoelectronic Technology, University of Science and Technology of China, Hefei, 230026, China; Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
² College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
³ School of Environment Science and Optoelectronic Technology, University of Science and Technology of China, Hefei, 230026, China; Institute of Intelligent Machines, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.
⁴ Sino-Canada Concord School of Hefei High Tech Zone, Hefei, 230088, China.
⁵ School of Environment Science and Optoelectronic Technology, University of Science and Technology of China, Hefei, 230026, China; Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. Electronic address: [email protected].
⁶ School of Environment Science and Optoelectronic Technology, University of Science and Technology of China, Hefei, 230026, China; Institute of Intelligent Machines, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. Electronic address: [email protected].
⁷ School of Environment Science and Optoelectronic Technology, University of Science and Technology of China, Hefei, 230026, China; Institute of Solid State Physics, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. Electronic address: [email protected].

PMID: 39788074
DOI: 10.1016/j.talanta.2025.127552

Abstract

Precise detection of ultralow-level antibiotics, such as picomole, in aqueous environments is significant for human health, however, it presents a great challenge to the adsorption capacity and electrocatalytic ability of sensing materials. Here, we used a one-step hydrothermal method to in situ grow spindle-like CoFe-based metal-organic frameworks (MOFs) with a size of about 50 nm in the region of hydrophilic MXene-loading hydrophobic carbon paper. By combining MOFs with abundant adsorption sites and MXene with high conductivity, the problems of adsorption and electrons transfer of ultralow-level antibiotics have been solved, and achieving precise detection of picomole-level antibiotics. As a result, the CoFe-MOFs/MXene/HCP sensing electrode exhibits the ultralow limit of detection with 33 pM and a wide detection range with 0.1 nm-2.0 mM for chloramphenicol (CAP) detection, as well as the designed sensor has excellent anti-interference, reproducibility, and stability. Importantly, the prepared sensing electrode exhibits reliable analytical results for CAP in real water samples, such as bottled water, milk, and urine, indicating that the prepared sensors have a great potential for application in the analysis of antibiotics in real samples.

Keywords: Detection of antibiotics; Electrochemical sensor; MXene; Metal-organic frameworks.