pks+E. coli adhesins-The fine line between good and evil

Chi Chun Wong; Jun Yu

doi:10.1016/j.chom.2024.12.007

pks⁺E. coli adhesins-The fine line between good and evil

Cell Host Microbe. 2025 Jan 8;33(1):1-3. doi: 10.1016/j.chom.2024.12.007.

Authors

Chi Chun Wong¹, Jun Yu²

Affiliations

¹ Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
² Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: [email protected].

PMID: 39788090
DOI: 10.1016/j.chom.2024.12.007

Abstract

Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E. coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.

MeSH terms

Adhesins, Escherichia coli* / genetics
Adhesins, Escherichia coli* / metabolism
Bacterial Adhesion*
Colon / microbiology
Colorectal Neoplasms / microbiology
DNA Damage
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism
Escherichia coli* / genetics
Escherichia coli* / metabolism
Gastrointestinal Microbiome
Humans
Intestinal Mucosa / metabolism
Intestinal Mucosa / microbiology
Peptides / metabolism
Polyketides* / metabolism

Substances

Polyketides
colibactin
Adhesins, Escherichia coli
Peptides
Escherichia coli Proteins