Advanced-stage duodenal cancer in pregnancy

BMJ Case Rep. 2025 Jan 9;18(1):e260551. doi: 10.1136/bcr-2024-260551.

Abstract

This is a case report of a pregnant patient diagnosed with advanced-stage duodenal cancer in the second trimester. To the author's knowledge, there are no studies that describe the management of advanced duodenal cancer during pregnancy and this case highlights the importance of creating a multidisciplinary team and incorporating shared decision-making when discussing diagnostic workup and treatment options, including the use of cytotoxic therapy during pregnancy, with patients. This study will also discuss maternal and fetal outcomes after the administration of FOLFOX (leucovorin, fluorouracil and oxaliplatin) chemotherapy during the second trimester.

Keywords: Cancer - see Oncology; Gastric cancer; Obstetrics, gynaecology and fertility.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols* / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols* / therapeutic use
  • Duodenal Neoplasms* / drug therapy
  • Duodenal Neoplasms* / pathology
  • Female
  • Fluorouracil* / administration & dosage
  • Fluorouracil* / therapeutic use
  • Humans
  • Leucovorin* / administration & dosage
  • Leucovorin* / therapeutic use
  • Organoplatinum Compounds / administration & dosage
  • Organoplatinum Compounds / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Neoplastic* / diagnosis
  • Pregnancy Complications, Neoplastic* / drug therapy
  • Pregnancy Trimester, Second

Substances

  • Leucovorin
  • Fluorouracil
  • Organoplatinum Compounds

Supplementary concepts

  • Folfox protocol