Fluoxetine-induced Seizure: A Case Report and Review of Literature

Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is one of the most widely prescribed antidepressant drugs in the United States due to its safety and efficacy. SSRIs are the first-line treatment for major depressive disorder and are also indicated for anxiety disorders, eating disorders, bipolar disorder, post-traumatic stress disorder, and obsessive-compulsive disorder. Common side effects of SSRIs include insomnia, nausea, anxiety, headache, weight change, sexual dysfunction, and suicide risk. Seizures are a less common side effect of fluoxetine. This article presents the case of 19-year-old transgender male patient who developed seizures as a side effect of an intentional overdose of fluoxetine. Although marketed frequently as a safe medication, providers should be aware of the adverse effects of fluoxetine.