Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance

Li Ding; Mingwang Chen; Xiaomei Li; Yuting Wu; Jingxu Li; Shuting Deng; Yikai Xu; Zhao Chen; Chenggong Yan

doi:10.1186/s13244-024-01888-1

Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance

Insights Imaging. 2025 Jan 10;16(1):11. doi: 10.1186/s13244-024-01888-1.

Authors

Li Ding¹, Mingwang Chen¹, Xiaomei Li¹, Yuting Wu¹, Jingxu Li^{1

2}, Shuting Deng¹, Yikai Xu³, Zhao Chen⁴, Chenggong Yan⁵

Affiliations

¹ Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
² Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
³ Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [email protected].
⁴ Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [email protected].
⁵ Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [email protected].

Abstract

Objectives: To investigate the image quality and diagnostic performance with ultra-low dose dual-layer detector spectral CT (DLSCT) by various reconstruction techniques for evaluation of pulmonary nodules.

Materials and methods: Between April 2023 and December 2023, patients with suspected pulmonary nodules were prospectively enrolled and underwent regular-dose chest CT (RDCT; 120 kVp/automatic tube current) and ultra-low dose CT (ULDCT; 100 kVp/10 mAs) on a DLSCT scanner. ULDCT was reconstructed with hybrid iterative reconstruction (HIR), electron density map (EDM), and virtual monoenergetic images at 40 keV and 70 keV. Quantitative and qualitative image analysis, nodule detectability, and Lung-RADS evaluation were compared using repeated one-way analysis of variance, Friedman test, and weighted kappa coefficient.

Results: A total of 249 participants (mean age ± standard deviation, 50.0 years ± 12.9; 126 male) with 637 lung nodules were included. ULDCT resulted in a significantly lower mean radiation dose than RDCT (0.3 mSv ± 0.0 vs. 3.6 mSv ± 0.8; p < 0.001). Compared with RDCT, ULDCT EDM showed significantly higher signal-noise-ratio (44.0 ± 77.2 vs. 4.6 ± 6.6; p < 0.001) and contrast-noise-ratio (26.7 ± 17.7 vs. 5.0 ± 4.4; p < 0.001) with qualitative scores ranked higher or equal to the average. Using the regular-dose images as a reference, ULDCT EDM images had a satisfactory nodule detection rate (84.6%) and good inter-observer agreements compared with RDCT (κw > 0.60).

Conclusion: Ultra-low dose dual-layer detector CT with 91.2% radiation dose reduction achieves sufficient image quality and diagnostic performance of pulmonary nodules.

Critical relevance statement: Dual-layer detector spectral CT enables substantial radiation dose reduction without impairing image quality for the follow-up of pulmonary nodules or lung cancer screening.

Key points: Radiation dose is a major concern for patients requiring pulmonary nodules CT screening. Ultra-low dose dual-layer detector spectral CT with 91.2% dose reduction demonstrated satisfactory performance. Dual-layer detector spectral CT has the potential for lung cancer screening and management.

Keywords: Dual-layer detector CT; Image quality; Pulmonary nodule; Ultra-low dose CT.

Grants and funding

82271987/Natural Science Foundation of China