Percutaneous irreversible electroporation of renal cell carcinomas in an acquired solitary kidney: A primary study

J Cancer Res Ther. 2024 Dec 1;20(7):1997-2003. doi: 10.4103/jcrt.jcrt_16_24. Epub 2025 Jan 10.

Abstract

Objective: To evaluate the postoperative complications and prognosis of renal cell carcinoma (RCC) in a solitary kidney after irreversible electroporation (IRE).

Materials and methods: A total of 8 patients with 9 RCCs in a solitary kidney treated with computed tomography (CT)-guided IRE from February 2017 to September 2020 were retrospectively analyzed. Follow-up included contrast-enhanced CT or magnetic resonance imaging examinations at 1 day, 1 week, 1 month, 3 months, 6 months, 12 months, and each year after IRE and the evaluation of the incidence of postoperative complications, renal function changes, local tumor recurrence, and metastasis.

Results: Technical success was achieved in all 8 patients treated with IRE. No serious complications were observed. Recurrence or metastasis occurred in two patients. The renal function and hemoglobin values of the 8 patients before treatment and at the last follow-up showed no significant difference.

Conclusion: IRE is a relatively effective, safe, and feasible treatment for RCCs in a solitary kidney, which improved the effective survival and quality of life of these patients.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Renal Cell* / pathology
  • Carcinoma, Renal Cell* / surgery
  • Carcinoma, Renal Cell* / therapy
  • Electroporation* / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms* / pathology
  • Kidney Neoplasms* / surgery
  • Kidney Neoplasms* / therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Prognosis
  • Quality of Life
  • Retrospective Studies
  • Solitary Kidney* / complications
  • Tomography, X-Ray Computed
  • Treatment Outcome