Risky sexual behavior and associated factors among people with severe mental illness in Africa: A systematic review and meta-analysis

Background: Individuals, who suffer from severe mental illnesses (SMI), such as bipolar disorder (BD), schizophrenia (SCZ), and major depressive disorder (MDD), are more likely to engage in risky sexual behavior. A severe mental illness can lead to a decrease in impulse control, a reduction in cognitive function and memory, and a psychosocial impairment that increases risky sexual behavior. Risky sexual behavior (RSB) can lead to health problems such as sexually transmitted infections, including HIV/AIDS, early pregnancy, and unplanned pregnancies. The purpose of this systematic review and meta-analysis was to determine the pooled prevalence of risky sexual behavior and factors among individuals with severe mental illness in Africa.

Method: A systematic review of observational studies: cross-sectional and prospective cohort studies published between 2009 and 2022 that reported relative risks (RR) and odd ratios (OR) that had explicit the prevalence of RSB. We conducted primary article searches in PubMed/MEDLINE, Scopus, African Journal Online, PsycINFO, EMBASE, Psychiatry Online, CINAHL, Science Direct, and the Cochrane Library. This review's included studies were critically appraised, and those with scores >5 were included in the meta-analysis. Meta-regression was used to investigate other reasons for heterogeneity in the dataset.

Results: This systematic review and meta-analysis includes twelve main studies with a total of 3625 participants, of whom 1605 were male and 2020 were female. The pooled prevalence of RSB among people with severe mental illness in Africa was 43.4 % (95 % CI 34.56-52.23). Being male OR = 2.83 (95 % CI 1.96-4.08), having active mania symptoms OR = 2.07(95 % CI 1.35-3.18), young adults OR = 2.79 (95 % CI 1.27-6.16), and current use of alcohol OR = 2.55 (95 % CI 1.71-3.79) were significantly associated with risky sexual behavior in this review.

Conclusion: This systematic review and meta-analysis revealed a high prevalence of risky sexual behavior (RSB) among individuals with severe mental illness in Africa, highlighting a critical public health concern. Several important factors were significantly associated with RSB in this population: being male, having active mania symptoms, young adults, and current alcohol use. These findings emphasize the need for targeted interventions and comprehensive support systems to address the behavioral and environmental risk factors that contribute to RSB in individuals with severe mental illness. Preventive strategies, including gender-sensitive approaches, integrated mental health and substance use services, and age-specific interventions, are essential to mitigate the risks associated with RSB and improve overall well-being in this vulnerable population.