Lung cancer is one of the most malignant tumor, representing a significant threat to human health. In China, its mortality rate is the highest among all malignant tumors. The occurrence of drug resistance has resulted in unfavourable prognosis for patients with lung cancer, and overcoming drug resistance is a significant challenge that needs to be addressed. Nano-drug delivery technology has been an important approach to overcome drug resistance in lung cancer. Targeting to the mechanisms of drug resistance, by enabling the combined delivery of drugs, increasing the efficiency of drug delivery and improving the targeting and safety of drugs, nano-drug delivery technology offers a novel approach to tackling drug resistance in lung cancer. This paper describes the current status of lung cancer treatment, mechanisms of drug resistance, strategies to overcome drug resistance, and the application of nanotechnology in the diagnosis and treatment of lung cancer. In addition, it summarizes the recent research progress on the application of nano-drug delivery technology to overcome drug resistance in lung cancer. Finally, the current prospects and challenges of nano-drug delivery technology are discussed. .
【中文题目：纳米药物递送技术在克服肺癌耐药性中的应用】 【中文摘要：肺癌是严重危害人类健康的恶性肿瘤之一，其死亡率在我国所有恶性肿瘤中位列第一。耐药的发生是导致肺癌患者生存结局不容乐观的重要因素，如何克服肺癌耐药性已成为亟待攻克的难题之一。纳米药物递送技术目前已成为克服肺癌耐药性的一种重要手段。针对肺癌发生耐药的机制，采用纳米药物递送技术可实现药物的联合递送、提高药物递送效率、增强药物靶向性和安全性等，为克服肺癌耐药提供了新思路。本文阐述了肺癌治疗的现状、发生耐药的机制及克服耐药性的策略，介绍了纳米技术在肺癌诊断和治疗过程中的应用，综述了纳米药物递送技术在克服肺癌耐药性应用中的最新研究进展，讨论了纳米药物递送技术的发展前景和目前面临的挑战。 】 【中文关键词：肺肿瘤；纳米药物递送技术；耐药】.
Keywords: Drug resistance; Lung neoplasms; Nano-drug delivery technology.