The design of acidic oxygen evolution reaction (OER) electrocatalysts with high activity and durability is the key to achieving efficient hydrogen production. Herein, we report a Cr-doped RuO2 (Ru0.9Cr0.1O2) catalyst that exhibits good OER activity in acidic electrolytes. The doping of Cr increases the valence state of Ru, which enhances the activity of the catalyst, and a current density of 10 mA cm-2 can be achieved at only 235 mV, which is superior to that of unmodified RuO2 of 299 mV. The Tafel slope of the catalyst was 63.9 mV dec-1, which is much better than that of unmodified RuO2 at 91.1 mV dec-1. In addition, this catalyst was able to maintain stable catalytic performance in 0.5 M H2SO4 for up to 30 hours. Density functional theory (DFT) calculations also showed that Cr doping optimized the adsorption of intermediates at Ru sites and significantly increased the catalytic activity of the Ru sites.