Objective: To investigate the current status of life stress and hypertension among couples of childbearing age across diverse economic regions in China, and to explore relevant influencing factors. Methods: This study was a cross-sectional study, with subjects from the "Research on the standardized system of comprehensive prevention and control of birth defects based on preconception-prenatal-postnatal whole chain". From February to May 2021, urban and rural couples of childbearing age (18-49 years old) from Beijing, Henan, and Gansu provinces were enrolled, representing the eastern, central, and western regions of China, respectively. The detection rate, cognition and control of hypertension in the general population, as well as the detection rate of hypertension in different genders and regions were analyzed. Subjects were divided into hypertensive group and non-hypertensive group based on whether their blood pressure was≥140/90 mmHg (1 mmHg=0.133 kPa), and the general clinical data of the two groups were compared. Subjects were also divided into prehypertension and hypertension group and normal blood pressure group based on whether their blood pressure was≥130/80 mmHg, and the general clinical data of the two groups were compared, with subgroup analyses conducted by gender. Multifactorial logistic regression model was applied to identify factors associated with prehypertension and hypertension in both males and females. Results: A total of 1 942 couples of childbearing age, comprising 3 884 individuals, aged (29.8±5.2) years were enrolled, with 1 942 males (50.0%). The overall hypertension detection rate was 6.3% (246/3 884), with a detection rate of 10.5% (203/1 942) in males and 2.2% (43/1 942) in females. The hypertension detection rates in Beijing, Henan, and Gansu were 6.2% (92/1 482), 11.6% (139/1 200), and 1.2% (15/1 202), respectively. The overall detection rate of prehypertension and hypertension was 40.5% (1 574/3 884). Multifactorial logistic regression analysis showed that life pressure factors had no effect on female blood pressure levels (P>0.05), while a significant or high level of life/work pressure was a risk factor for prehypertension and hypertension in males (OR=2.30, 95%CI 1.06-4.99, P<0.05). Conclusion: The detection rate of prehypertension and hypertension among young couples of childbearing age in China is high, with poor awareness and control of hypertension. There are sex differences in the relationship between life pressure and blood pressure levels. Comprehensive consideration of individual living environments and mental health factors is crucial in blood pressure management. Measures to reduce life stress and enhance mental resilience should be implemented to address this public health issue.
目的： 调查我国不同省份及不同经济发展地区青年育龄夫妇生活压力和血压水平现状，并分析影响青年育龄夫妇血压水平的相关因素。 方法： 本研究为横断面研究。研究对象来自“基于孕前-产前-生后全链条的出生缺陷综合防控规范化体系研究”。入选2021年2—5月上述研究中来自我国东、中、西部地区（北京市、河南省、甘肃省）18~49岁之间的城市和农村的育龄夫妇，分析总体人群的高血压检出率、认知及控制情况以及不同性别和地区的高血压检出率。根据血压是否≥140/90 mmHg（1 mmHg=0.133 kPa）将研究对象分为高血压组和非高血压组，比较两组的一般临床资料。根据血压是否≥130/80 mmHg将研究对象分为高血压前期及高血压组和血压正常组，比较两组的一般临床资料，并根据性别进行亚组分析。应用多因素logistic回归模型分析男性及女性高血压前期及高血压的影响因素。 结果： 纳入1 942 对育龄夫妇共3 884人，年龄（29.8±5.2）岁，男性1 942人（50.0%）。总体人群高血压检出率为6.3%（246/3 884），男性高血压检出率为10.5%（203/1 942），女性高血压检出率为2.2%（43/1 942）。北京市高血压检出率为6.2%（92/1 482），河南省高血压检出率为11.6%（139/1 200），甘肃省高血压检出率为1.2%（15/1 202）。总体人群高血压前期及高血压检出率为40.5%（1 574/3 884）。多因素logistic回归分析结果显示，生活压力因素对女性血压水平无影响（P>0.05），而比较大或很大的生活/工作压力是男性高血压前期及高血压的危险因素（OR=2.30，95%CI 1.06~4.99，P<0.05）。 结论： 我国青年育龄人群高血压前期及高血压检出率较高，高血压认知和控制情况不佳。生活压力与血压水平之间的关系存在一定性别差异。在血压管理中需要更全面地考虑个体生活环境和心理健康因素，采取措施来减轻生活压力和提高心理韧性。.