Differential Gene Set Enrichment of Epithelial-Mesenchymal Transition Pathway in BRAF vs. NRAS Mutated Metastatic Melanoma

Victor J Raimundi-Santos; Tyrel R Porter

doi:10.1093/ced/llaf023

Differential Gene Set Enrichment of Epithelial-Mesenchymal Transition Pathway in BRAF vs. NRAS Mutated Metastatic Melanoma

Clin Exp Dermatol. 2025 Jan 15:llaf023. doi: 10.1093/ced/llaf023. Online ahead of print.

Authors

Victor J Raimundi-Santos¹, Tyrel R Porter²

Affiliations

¹ School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
² School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico.

PMID: 39813282
DOI: 10.1093/ced/llaf023

Abstract

This study investigates the differential activation of the epithelial-mesenchymal transition (EMT) pathway in metastatic melanoma, focusing on BRAF- and NRAS-mutated samples from The Cancer Genome Atlas (TCGA). Gene Set Enrichment Analysis (GSEA) reveals that BRAF mutations are more significantly associated with increased EMT activation, relative to all other mutations in the dataset. In contrast, NRAS mutations were not significantly associated with gene expression of the EMT pathway, suggesting alternative mechanisms for metastasis.

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