Advances in the development of microarray patches in biomedicine

Pooyan Makvandi; Rezvan Jamaledin; Mohammad Mofidfar; Xiangdong Wang; Tae Seok Moon

doi:10.1016/j.nbt.2025.01.003

Advances in the development of microarray patches in biomedicine

N Biotechnol. 2025 Jan 14:86:25-30. doi: 10.1016/j.nbt.2025.01.003. Online ahead of print.

Authors

Pooyan Makvandi¹, Rezvan Jamaledin², Mohammad Mofidfar³, Xiangdong Wang⁴, Tae Seok Moon⁵

Affiliations

¹ The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, China.
² University of Bath, Department of Life Sciences, Claverton Down, Bath BA2 7AY, United Kingdom.
³ Department of Chemistry, Stanford University, Stanford, CA 94305, United States.
⁴ Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai 200032, China.
⁵ Synthetic Biology Group, J. Craig Venter Institute, La Jolla, CA 92037, United States. Electronic address: [email protected].

PMID: 39814261
DOI: 10.1016/j.nbt.2025.01.003

Abstract

Microarray patches (MAPs) have been employed to deliver therapeutic payloads and for detection purposes. Research has been conducted to develop novel designs in material chemistry and the architecture of microarray, which have opened up the possibility for broader applications of MAPs. However, MAPs have yet to be clinically implemented fully. Addressing the current challenges and maximizing opportunities will pave the way to translate the relevant technologies from bench to bedside.

Keywords: Clinical translation; Drug delivery; Mass production; Microarray patches.