Kidney Arteriolar Responses to Liver-Targeted Small Interference RNA Targeting Angiotensinogen in Diabetic Rats: Comparison With Other Renin-Angiotensin System Blockers

J Am Heart Assoc. 2025 Jan 16:e038326. doi: 10.1161/JAHA.124.038326. Online ahead of print.

Authors

Edwyn O Cruz-López¹, Alexandre G Martini^{2

3}, Don Foster⁴, Ivan Zlatev⁴, Anne Kasper⁴, Maria Luisa S Sequeira-Lopez², Ariel Gomez², A H Jan Danser¹

Affiliations

¹ Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center Rotterdam The Netherlands.
² Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine Charlottesville VA.
³ Molecular Pharmacology Laboratory University of Brasília Brazil.
⁴ Alnylam Pharmaceuticals Cambridge MA.

PMID: 39817539
DOI: 10.1161/JAHA.124.038326

No abstract available

Keywords: angiotensinogen; arteriolar concentric thickening; diabetes; hypertension; small interfering RNA.