Cytokine storm can occur in many different clinical conditions and lack of recognition can lead to death. While cytokines have been measured and trended in burn patients, cytokine storm has not been widely discussed or its treatment reported. We present herein the diagnosis and the treatment of a 5-year-old, 91% burn patient, who developed cytokine storm three times during his hospital course. Aggressive treatment led to successful resolution. Cytokine storm should be entertained in patients who develop classic storm signs and symptoms, along with supporting laboratory. Treatment should be tailored to the patients' clinical picture. More study is warranted to define cytokine storm as well as its treatment in burn patients.
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Burn Association.