Establishing Minimally Important Difference Thresholds for Lesion Counts in Acne Clinical Studies

John S Barbieri; Susan S Ellenberg; Ann Tierney; Suzette Baez VanderBeek; Maryte Papadopoulos; Jennifer Mason; Anabel Mason; James Dattilo; David J Margolis

doi:10.1016/j.jaad.2025.01.015

Establishing Minimally Important Difference Thresholds for Lesion Counts in Acne Clinical Studies

J Am Acad Dermatol. 2025 Jan 15:S0190-9622(25)00054-4. doi: 10.1016/j.jaad.2025.01.015. Online ahead of print.

Authors

John S Barbieri¹, Susan S Ellenberg², Ann Tierney², Suzette Baez VanderBeek², Maryte Papadopoulos², Jennifer Mason², Anabel Mason², James Dattilo³, David J Margolis⁴

Affiliations

¹ Department of Dermatology, Brigham and Women's Hospital, Boston, MA. Electronic address: [email protected].
² Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA.
³ Clinical Research Collaboration Unit, University of Pennsylvania, PhiladelphiaPA.
⁴ Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA.

PMID: 39824353
DOI: 10.1016/j.jaad.2025.01.015

No abstract available

Keywords: acne; comedones; comparative effectiveness; inflammatory; minimally important change; minimally important difference; non-inferiority; non-inflammatory.