Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

Jiayou Jiang; Yunqian Zhang; Jiyi Wang; Yixin Qin; Chonguang Zhao; Kai He; Chaoming Wang; Yucheng Liu; Haoyu Feng; Huiling Cai; Shulei He; Ruiyu Li; David S Galstyan; Longen Yang; Lee Wei Lim; Murilo S de Abreu; Allan V Kalueff

doi:10.1111/jnc.16311

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

J Neurochem. 2025 Jan;169(1):e16311. doi: 10.1111/jnc.16311.

Authors

Jiayou Jiang^{1

2}, Yunqian Zhang^{1

2}, Jiyi Wang^{1

2}, Yixin Qin^{1

2}, Chonguang Zhao^{1

2}, Kai He^{1

2}, Chaoming Wang^{1

2}, Yucheng Liu^{1

2}, Haoyu Feng^{1

2}, Huiling Cai^{1

2}, Shulei He^{1

2}, Ruiyu Li^{1

2}, David S Galstyan^{3

4}, Longen Yang^{1

2}, Lee Wei Lim^{1

2}, Murilo S de Abreu^{5

6

7}, Allan V Kalueff^{1

2

6}

Affiliations

¹ Suzhou Municipal Key Laboratory of Neurobiology and Cell Signaling, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
² Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
³ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
⁴ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁵ Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
⁶ Moscow Institute of Physics and Technology, Moscow, Russia.
⁷ Western Caspian University, Baku, Azerbaijan.

PMID: 39825734
DOI: 10.1111/jnc.16311

Abstract

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications of coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models are presently widely used in neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful and promising alternative model species. Mounting evidence supports the importance of RNA modifications in zebrafish CNS function, providing additional insights into epitranscriptomic mechanisms underlying a wide range of brain disorders. Here, we discuss recent data on the role of RNA modifications in CNS regulation, with a particular focus on zebrafish models, as well as evaluate current problems, challenges, and future directions of research in this field of molecular neurochemistry.

Keywords: RNA modifications; epitranscriptomic modifications; epitranscriptomics; molecular neurochemistry; zebrafish.

Publication types

Review

MeSH terms

Animals
Central Nervous System / metabolism
Disease Models, Animal
Epigenesis, Genetic* / genetics
Epigenesis, Genetic* / physiology
Humans
RNA Processing, Post-Transcriptional / genetics
Transcriptome
Zebrafish*

Abstract

Publication types

MeSH terms

Grants and funding