Objective: To describe the distribution characteristics of alcohol consumption in adult twins in the Chinese National Twin Registry (CNTR), and further explore the influence of genetic factors on alcohol consumption in adult twins. Methods: The subjects of the study were twins registered by CNTR in 11 project areas across China from 2010 to 2018. A total of 56 966 twins (28 483 pairs) aged 18 years and above who answered questions about drinking behavior were included, and the random effect model was used to describe the population and regional distribution characteristics of alcohol consumption. Intra-pair analysis was performed to calculate the concordance rate and heritability of their alcohol consumption. Results: The age of all subjects was (36.6±12.0) years, and current drinkers accounted for 16.6% (9 461/56 966) of all subjects. In men, those aged 50-59 years, those in northern China, those living in rural area, those with low education level and those with high BMI, the proportions of current drinkers were higher. After excluding 468 pairs of twins who had stopped alcohol use and 21 764 pairs of twins who had no drink or had small amount drink, an intra-pair analysis was conducted in 4 929 pairs of same-sex twins, and found that the concordance rate of alcohol consumption was 64.0% (2 059/3 215) in monozygotic twins, and 52.6% (902/1 714) in dizygotic twins, the difference was significant (P<0.001), and the heritability of alcohol consumption was 24.1% (95%CI: 18.9%- 29.3%). The further stratified analysis found that in southern men, the heritability was highest in those aged 40-49 years (36.1%, 95%CI: 21.6%-50.7%), while in northern men, the heritability was highest in those aged 50-59 years (34.2%, 95%CI: 18.1%-50.3%). Conclusions: In adult twins in China, there were population and regional differences in the distribution of alcohol consumption behavior, and alcohol consumption was influenced by genetic factors, and gender, age and region had potential modifying effects.
目的： 描述中国双生子登记系统（CNTR）中成年双生子饮酒行为的分布特征，并进一步探究遗传因素对饮酒行为的影响。 方法： 研究对象为2010-2018年CNTR在全国11个项目地区登记的双生子，共纳入56 966名（28 483对）≥18岁且回答饮酒行为相关问题的双生子，使用随机效应模型描述饮酒行为的人群、地区分布特征。进行双生子对内分析，计算饮酒行为一致率和遗传度。 结果： 研究对象年龄为（36.6±12.0）岁，全部研究对象中当前饮酒者占比为16.6%（9 461/56 966）。在男性、50~59岁组、北方、乡村、高中及以下文化程度、超重/肥胖人群中当前饮酒者占比较高。剔除有戒酒行为的468对双生子、21 764对不饮/轻度饮酒的双生子后，在4 929对同性别双生子中进行对内分析发现，同卵双生子饮酒一致率为64.0%（2 059/3 215），异卵双生子为52.6%（902/1 714），差异有统计学意义（P<0.001），饮酒行为遗传度为24.1%（95%CI：18.9%~29.3%）。进一步分层分析后发现，在南方男性中，遗传度在40~49岁人群中最高［36.1%（95%CI：21.6%~50.7%）］，而在北方男性中，遗传度在50~59岁人群中最高［34.2%（95%CI：18.1%~50.3%）］。 结论： 在我国成年双生子中，饮酒行为的分布存在人群和地区差异，饮酒行为受到遗传因素的影响，性别、年龄和地区具有潜在的修饰作用。.