A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nat Commun. 2025 Jan 20;16(1):860. doi: 10.1038/s41467-025-56110-7.

Abstract

Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous H2O2 and O2. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBiVO3-PEG) can generate reactive oxygen species in an excitation-free and H2O2- and O2-independent manner. Upon exposure to the tumor microenvironment, NaBiVO3-PEG undergoes continuous H+-accelerated hydrolysis with •OH and 1O2 generation through electron transfer-mediated BiV-to-BiIII conversion and lattice oxygen transformation. The simultaneous release of sodium counterions after endocytosis triggers caspase-1-mediated pyroptosis. NaBiVO3-PEG intratumorally administered initiates robust therapeutic efficacies against both primary and distant tumors and activates systemic immune responses to combat tumor metastasis. NaBiVO3-PEG intravenously administered can efficiently accumulate at the tumor site for further real-time computed tomography monitoring, immunotherapy, or alternative synergistic immune-radiotherapy. Overall, this work offers a nanomedicine based on high-valence bismuth(V) nanoplatform and underscores its great potential for cancer immunotherapy.

MeSH terms

  • Animals
  • Bismuth* / chemistry
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Female
  • Humans
  • Hydrogen Peroxide* / metabolism
  • Immunotherapy / methods
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles / chemistry
  • Neoplasms / drug therapy
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Oxygen / metabolism
  • Polyethylene Glycols / chemistry
  • Reactive Oxygen Species* / metabolism
  • Tumor Microenvironment* / drug effects
  • Tumor Microenvironment* / immunology

Substances

  • Bismuth
  • Hydrogen Peroxide
  • Reactive Oxygen Species
  • Oxygen
  • Polyethylene Glycols