Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells

Science. 1985 May 3;228(4699):580-2. doi: 10.1126/science.3983641.

Abstract

The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Ataxia Telangiectasia / genetics
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Chromosome Mapping*
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 6-12 and X
  • Female
  • Humans
  • Male
  • Mice
  • Receptors, Antigen, T-Cell / genetics*

Substances

  • Receptors, Antigen, T-Cell