Two-fluid flow of blood in a curved stenotic artery under pulsating condition

J Biol Phys. 2025 Jan 22;51(1):6. doi: 10.1007/s10867-024-09668-0.

Abstract

The present article focuses on the analysis of the two-phase flow of blood via a stenosed artery under the influence of a pulsatile pressure gradient. The core and plasma regions of flow are modeled using the constitutive relations of Herschel-Bulkley and the Newtonian fluids, respectively. The problem is modeled in a cylindrical coordinate system. A modest stenosis assumption is used to simplify the non-dimensional governing equations of the flow issue. An explicit finite difference approach is used to solve the resultant nonlinear system of differential equations while accounting for the provided boundary conditions. After the necessary adjustments have been made to the crucial non-dimensional parameters, an analysis of the data behind the huge image, such as axial velocity, temperature field, concentration wall shear stress, flow rate, and flow impedance, is conducted. The current study shows that the curvature of blood vessels plays a significant role in influencing blood velocity. Specifically, a unit increase in the curvature radius results in a 24% rise in blood velocity.

Keywords: Explicit finite differences method; Herschel-Bulkley fluid; Pulsatile flow; Resistance to flow; Rigid stenotic artery; Wall shear stress.

MeSH terms

  • Arteries* / physiopathology
  • Blood Flow Velocity
  • Constriction, Pathologic
  • Humans
  • Models, Cardiovascular
  • Pulsatile Flow*