Rational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy

The increasing prevalence of antibiotic resistance, driven by the overuse and misuse of conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated by photothermal agents under light exposure to inhibit bacterial growth without inducing resistance, attracting more and more attention. Quinoid conjugated polymers, especially para-azaquinodimethane (AQM) polymer, are a class of organic semiconductors known for efficient π-electron delocalization, near-infrared absorption, and narrow bandgap, showing great potential in the application of photothermal reagents. However, current AQM polymers face challenges related to their solubility, photostability, and biocompability. In this study, tetraglycol is introduced onto the AQM core for improving the drawbacks of the resulting polymers. Two AQM polymers with different electron donor (thiophene and 2,2'-bithiophene) are synthesized and evaluated for their various properties. PAQMT exhibited superior performance, including higher extinction coefficients, improved light absorption, and greater stability under repeated NIR irradiation. PAQMT is further developed into nanoparticles via encapsulation, resulting in excellent colloidal stability, effective bacterial inhibition under 808 nm NIR light. This work provides new strategy in improving the solubility, photostability, and photothermal properties of AQM polymers, offers opportunities for promoting the application of quinoidal conjugated polymers in PTAT.