Expert consensus on classification and diagnosis of congenital orofacial cleft
Hua Xi Kou Qiang Yi Xue Za Zhi. 2025 Feb 1;43(1):1-14.
doi: 10.7518/hxkq.2025.2024306.
[Article in
English,
Chinese]
Authors
Chenghao Li
1
, Yang An
2
, Xiaohong Duan
3
, Yingkun Guo
4
, Shanling Liu
5
, Hong Luo
6
, Duan Ma
7
, Yunyun Ren
8
, Xudong Wang
9
, Xiaoshan Wu
10
, Hongning Xie
11
, Hongping Zhu
12
, Jun Zhu
13
, Bing Shi
1
Affiliations
- 1 State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
- 2 Dept. of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China.
- 3 Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, Air Force Medical University, Xi'an 710032, China.
- 4 Dept. of Radiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- 5 Dept. of Medical Genetics/Dept. of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- 6 Dept. of Ultrasonography/Dept. of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- 7 Lab of Birth Defects Research, Fudan University, Shanghai 200438, China.
- 8 Dept. of Ultrasonics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China.
- 9 Dept. of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.
- 10 Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital of Central South University, Changsha 410008, China.
- 11 Dept. of Medical Ultrasonics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
- 12 Dept. of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
- 13 National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Congenital orofacial cleft, the most common birth defect in the maxillofacial region, exhibits a wide range of prognosis depending on the severity of deformity and underlying etiology. Non-syndromic congenital orofacial clefts typically present with milder deformities and more favorable treatment outcomes, whereas syndromic congenital orofacial clefts often manifest with concomitant organ abnormalities, which pose greater challenges for treatment and result in poorer prognosis. This consensus provides an elaborate classification system for varying degrees of orofacial clefts along with corresponding diagnostic and therapeutic guidelines. Results serve as a crucial resource for families to navigate prenatal screening results or make informed decisions regarding treatment options while also contributing significantly to preventing serious birth defects within the development of population.
先天口面裂是颌面部最常见的出生缺陷，其预后根据畸形的病因和严重程度的不同有着很大的差别。其中非综合征型先天口面裂的畸形程度较轻且治愈效果好，综合征型先天口面裂常因伴有身体其他器官的异常而致使治疗难度较大，预后较差。本共识对不同严重程度的先天口面裂进行详细的分级分类，并提出相应的诊疗指南，为患者家庭应对产前筛查结果、选择治疗方案提供参考，对我国预防和控制严重出生缺陷发生、促进人口长期均衡发展具有重要意义。.
Keywords:
classification; congenital orofacial cleft; diagnosis and therapy.
MeSH terms
-
Cleft Lip* / classification
-
Cleft Lip* / diagnosis
-
Cleft Palate* / diagnosis
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Consensus
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Humans
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Prenatal Diagnosis