Frequency and Predictors of Conversion From Laparoscopic to Open Cholecystectomy: A Single-Center Observational Study

Objective: The study aimed to investigate the rate of conversion from laparoscopic cholecystectomy (LC) to open cholecystectomy (OC) in our population and determine the potential risk factors associated with it. Understanding these factors helps surgeons predict complex cases and plan surgeries, reducing patient risks and improving outcomes.

Methodology: A cross-sectional observational study was conducted from June 1, 2022, to May 31, 2023, at Hayatabad Medical Complex, Peshawar, on 349 patients undergoing elective LC. Data on demographics, clinical history, laboratory values, and imaging findings were recorded using a standardized proforma. Intraoperative findings, surgical outcomes, and complications were noted, with statistical analysis performed using IBM SPSS Statistics for Windows, Version 23.0 (Released 2015; IBM Corp., Armonk, New York, United States). Chi-squared, Mann-Whitney U, and logistic regression tests assessed the associations and risk factors of conversion to open surgery.

Results: The rate of conversion from LC to OC was found to be 13 (3.7%). The multivariate analysis revealed several significant risk factors associated with the conversion. These included male gender, history of jaundice due to gallbladder stones, history of pancreatitis, gallbladder wall thickness greater than 3 mm, white blood cell counts greater than 1000 per microliter of blood, difficulty in handling the gallbladder with instruments intraoperatively, and dense adhesions with surrounding tissues (p<0.05). The risk factor summation pyramid showed a sensitivity of 84.6% and a specificity of 63.8% in predicting the likelihood of conversion, emphasizing the importance of considering each risk factor individually.

Conclusion: The rate of conversion to OC was 3.7%. Factors such as male gender, history of jaundice due to gallbladder stones, history of pancreatitis, thick gallbladder wall, high white blood cell count, difficulty in handling the gallbladder, and dense adhesions with surrounding tissues were significantly associated with conversion to OC.