Experience with the surgical treatment of 340 patients with chronic acalculous cholecystitis is described. In 56,5% of observations it was complicated by the involvement of organs of the hepatobiliopancreatic group. The authors stress the importance of a complex instrumental pre- and intra-operative examination which can reveal lesions not only in the gallbladder but also in the major bile ducts, liver and pancreas. The volume of operation in patients with acalculous cholecystitis must include measures correcting lesions of the hepatobiliopancreatic organs in addition to cholecystectomy. Long-term results were studied in 238 patients. Good results were obtained in 129 patients, satisfactory--in 80 patients, unsatisfactory results were noted in 29 patients which were due to chronic recurring pancreatitis.