Central nervous system-directed neuronotrophic activity present in red blood cells

L R Williams; I Selak; S D Skaper; M Manthorpe; S Varon

doi:10.1016/0006-8993(85)90420-2

Central nervous system-directed neuronotrophic activity present in red blood cells

Brain Res. 1985 Jun 10;336(1):99-105. doi: 10.1016/0006-8993(85)90420-2.

Authors

L R Williams, I Selak, S D Skaper, M Manthorpe, S Varon

PMID: 4005581
DOI: 10.1016/0006-8993(85)90420-2

Abstract

A new neuronotrophic factor has been identified in extracts of vertebrate red blood cells. The factor supports the survival in culture of neurons from vertebrate central nervous systems, and does not support the survival of several peripheral ganglionic neurons. The active molecule appears to be a slightly acidic protein of 30,000-100,000 daltons.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biological Assay
Brain
Cells, Cultured
Erythrocytes / analysis*
Female
Ganglia, Parasympathetic
Ganglia, Spinal
Nerve Growth Factors
Nerve Tissue Proteins / blood*
Nerve Tissue Proteins / pharmacology
Rats
Rats, Inbred Strains

Substances

Nerve Growth Factors
Nerve Tissue Proteins