Squamous cell carcinoma (SCC) of the head and neck developed in two patients 12 and 22 years, respectively, after radiation treatment for Hodgkin's disease (HD). Both tumors arose in previously irradiated fields. Sixteen reported cases of SCC of the head and neck occurring after treatment for HD are summarized. Details of treatment were lacking in most instances. The authors suspect that cases similar to the two reported here will be seen more frequently with longer follow-up of patients cured of HD.