Activity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria

Antimicrob Agents Chemother. 1985 Jun;27(6):961-3. doi: 10.1128/AAC.27.6.961.

Abstract

Alafosfalin, an antibacterial phosphonodipeptide requiring peptide transport for activity, was tested for activity against clinical strains of anaerobic bacteria in peptide-free Roche Sensitivity Test Medium no. 5 agar. It was active against Bacteroides spp., Fusobacterium nucleatum, and Clostridium perfringens but not against Clostridium difficile. Alafosfalin activity was antagonized by appropriate peptides. Synergy was obtained with other cell wall-active antibiotics.

MeSH terms

  • Alanine / analogs & derivatives*
  • Alanine / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria, Anaerobic / drug effects*
  • Culture Media
  • Cycloserine / pharmacology
  • Microbial Sensitivity Tests
  • Penicillin G / pharmacology

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • alafosfalin
  • Cycloserine
  • Alanine
  • Penicillin G