Abstract
New, seven-step synthesis of arylanalogs of ketamine, starting from easily available phenylcyclohexane derivatives, is reported. Pharmacological investigations on the compounds obtained are described.
MeSH terms
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Amphetamine / pharmacology
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Analgesics
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Animals
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Anticonvulsants
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Behavior, Animal / drug effects
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Blepharoptosis / chemically induced
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Body Temperature / drug effects
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Catalepsy / chemically induced
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Chemical Phenomena
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Chemistry
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Female
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Humans
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Ketamine / analogs & derivatives*
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Ketamine / pharmacology
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Ketamine / toxicity
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Lethal Dose 50
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Male
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Mice
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Mice, Inbred Strains
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Physostigmine / antagonists & inhibitors
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Rats
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Rats, Inbred Strains
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Reserpine / antagonists & inhibitors
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Stereotyped Behavior / drug effects
Substances
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Analgesics
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Anticonvulsants
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Ketamine
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Reserpine
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Physostigmine
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Amphetamine