Abstract
Pretreatment with baclofen prolonged the duration of fentanyl-induced analgesia from 18 to 30 min in patients undergoing neurosurgical anaesthesia (fentanyl plus nitrous oxide in oxygen). This observation is consistent with a potentiating effect of GABA on opioid analgesia.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Anesthesia, General*
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Baclofen / administration & dosage
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Baclofen / pharmacology*
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Drug Synergism
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Fentanyl / pharmacology*
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Humans
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Hypophysectomy
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Injections, Intramuscular
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Injections, Intravenous
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Male
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Middle Aged
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Nitrous Oxide
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Preanesthetic Medication
Substances
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Baclofen
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Nitrous Oxide
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Fentanyl