Digital radiography (DR) was compared with conventional chest radiography in patients with mediastinal adenopathy, sarcoidosis, and metastatic adenocarcinoma. Contrast resolution was improved by the new technique, offering a wider latitude and edge enhancement. While small, low-contrast details were resolved best by conventional radiography, DR was superior for resolution of nodules. With further improvement of spatial and contrast resolution, DR could become the preferred technique of chest radiography.