Studies on psychotropic drugs. 18. Synthesis and structure-activity relationships of 5-phenyl-1,3-dihydro-2H-thieno(2,3-e) (1,4) diazepin-2-ones

J Med Chem. 1973 Mar;16(3):214-9. doi: 10.1021/jm00261a010.
No abstract available

MeSH terms

  • Aggression / drug effects
  • Animals
  • Azepines / chemical synthesis*
  • Azepines / pharmacology
  • Azepines / toxicity
  • Behavior, Animal / drug effects
  • Central Nervous System / drug effects
  • Depression, Chemical
  • Electroshock
  • Female
  • Humans
  • Ketones / chemical synthesis
  • Ketones / pharmacology
  • Ketones / toxicity
  • Lethal Dose 50
  • Male
  • Mice
  • Motor Activity / drug effects
  • Olfactory Bulb / physiology
  • Pentylenetetrazole / antagonists & inhibitors
  • Rats
  • Sleep / drug effects
  • Structure-Activity Relationship
  • Thiophenes / chemical synthesis
  • Thiophenes / pharmacology
  • Thiophenes / toxicity
  • Tranquilizing Agents / chemical synthesis*
  • Tranquilizing Agents / pharmacology
  • Tranquilizing Agents / toxicity

Substances

  • Azepines
  • Ketones
  • Thiophenes
  • Tranquilizing Agents
  • Pentylenetetrazole