Plasma 17-hydroxyprogesterone in newborn infants with congenital adrenal hyperplasia and in infants with normal adrenal function

S M Atherden; A T Edmunds; D B Grant

doi:10.1136/adc.49.3.192

Plasma 17-hydroxyprogesterone in newborn infants with congenital adrenal hyperplasia and in infants with normal adrenal function

Arch Dis Child. 1974 Mar;49(3):192-4. doi: 10.1136/adc.49.3.192.

Authors

S M Atherden, A T Edmunds, D B Grant

Abstract

Plasma 17-hydroxyprogesterone (17-OHP) was estimated in 9 infants aged 6 to 12 days with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Raised plasma 17-OHP values, ranging from 3·4 to 25·0 μg/100 ml were found. 50 infants aged 10 hours to 15 days with normal adrenal function were also studied. One infant with galactosaemia had 17-OHP levels of 1·8 and 2·4 μg/100 ml, and a further 3 infants aged 15 hours to 3 days had 17-OHP levels between 1·1 and 2·1 μg/100 ml. In the remaining infants, plasma 17-OHP was less than 1·0 μg/100 ml. It therefore appears that estimation of plasma 17-OHP provides a useful method for confirming the diagnosis of CAH during the newborn period.

Publication types

Comparative Study

MeSH terms

Adrenal Hyperplasia, Congenital*
Adrenocortical Hyperfunction / diagnosis
Female
Humans
Hydroxyprogesterones / blood*
Hyperplasia / blood
Hyperplasia / congenital
Hyperplasia / diagnosis
Infant, Newborn
Infant, Newborn, Diseases / blood*
Male

Substances

Hydroxyprogesterones