Abstract
The preparation and antifungal properties of cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (I) are described. Ketoconazole has, at low oral doses, a high in vivi activity against vaginal candidosis in rats and against cutaneous candidosis in guinea pigs.
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Candidiasis / drug therapy
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Chemical Phenomena
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Chemistry
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Female
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Guinea Pigs
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Imidazoles / therapeutic use
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Miconazole / therapeutic use
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Rats
Substances
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Antifungal Agents
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Imidazoles
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Piperazines
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Miconazole