Abstract
The preparation and anthelmintic activities of a series of 2-pyridinyl-5-isothiocyanatobenzimidazoles are described. In the primary oral mouse screen, six derivatives showed 100% taeniacidal activity at 0.2% in diet. The most active member in this series, 1c, is potentially an effective gastrointestinal nematocide in sheep at 50 mg/kg po.
MeSH terms
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Animals
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Anthelmintics / chemical synthesis*
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Dogs
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Hymenolepiasis / drug therapy
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Mice
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Monieziasis / drug therapy
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Nematode Infections / drug therapy
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Parasite Egg Count
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Sheep
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Structure-Activity Relationship
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Taeniasis / drug therapy
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Thiocyanates / chemical synthesis*
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Thiocyanates / pharmacology
Substances
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Anthelmintics
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Benzimidazoles
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Thiocyanates