Abstract
An anomalous Ullman reaction with 2-chloronicotinic acid is described. The resulting product 2',6'-di-methyl-anilide of 2-pyridone-3-carboxylic acid (isonixine) presents very interesting pharmacological properties as a potential analgesic-anti-inflammatory agent. Chemical and pharmacological data are given.
MeSH terms
-
Administration, Oral
-
Analgesics / chemical synthesis
-
Anilides / chemical synthesis
-
Anilides / pharmacology
-
Anilides / toxicity
-
Animals
-
Anti-Inflammatory Agents / chemical synthesis*
-
Chemical Phenomena
-
Chemistry
-
Edema / chemically induced
-
Edema / physiopathology
-
Female
-
Lethal Dose 50
-
Male
-
Mice
-
Nicotinic Acids* / pharmacology
-
Nicotinic Acids* / toxicity
-
Rats
-
Suppositories
Substances
-
Analgesics
-
Anilides
-
Anti-Inflammatory Agents
-
Nicotinic Acids
-
Suppositories