Abstract
In attempt to improve distribution and transport qualities of antidotes against organophosphorus poisoning, a new series of pyridine aldoximes linked to glucose moiety were synthesized and studied both in vivo and in vitro. Preliminary results describing the biological activity of the new compounds are presented and discussed in this report.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antidotes / chemical synthesis*
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Cholinesterase Reactivators / chemical synthesis
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Cholinesterase Reactivators / pharmacology
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Cholinesterases / metabolism
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Eels
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Glucose / analogs & derivatives*
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Glucose / chemical synthesis
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Glucose / pharmacology
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Mice
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Organophosphate Poisoning*
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Pralidoxime Compounds / chemical synthesis*
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Pralidoxime Compounds / pharmacology
Substances
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Antidotes
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Cholinesterase Reactivators
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Pralidoxime Compounds
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Cholinesterases
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Glucose