Abstract
This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal
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Base Sequence
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Epitopes
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Mutation
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Oligopeptides
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Poliovirus / immunology
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Poliovirus Vaccine, Inactivated*
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Poliovirus Vaccine, Oral
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Protein Conformation
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Rabbits
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Vaccines, Attenuated
Substances
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Antibodies, Monoclonal
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Epitopes
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Oligopeptides
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Poliovirus Vaccine, Inactivated
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Poliovirus Vaccine, Oral
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Vaccines, Attenuated