New poliovirus vaccines: a molecular approach

Vaccine. 1984 Sep;2(3):177-84. doi: 10.1016/0264-410x(84)90081-1.

Abstract

This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Base Sequence
  • Epitopes
  • Mutation
  • Oligopeptides
  • Poliovirus / immunology
  • Poliovirus Vaccine, Inactivated*
  • Poliovirus Vaccine, Oral
  • Protein Conformation
  • Rabbits
  • Vaccines, Attenuated

Substances

  • Antibodies, Monoclonal
  • Epitopes
  • Oligopeptides
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccine, Oral
  • Vaccines, Attenuated