Expression of the 3' terminal region of human T-cell leukemia viruses

Science. 1984 Oct 12;226(4671):177-9. doi: 10.1126/science.6091270.

Abstract

Human T-cell leukemia viruses (HTLV) are closely associated with some human T-cell leukemias and lymphomas. A unique 3' region of the HTLV genome is believed to be involved in HTLV-induced cellular transformation, although the function of this region has yet to be determined. A subgenomic messenger RNA transcribed from this region of HTLV has now been characterized. These results provide direct evidence for the expression of a novel gene in HTLV.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Transformation, Viral
  • Deltaretrovirus / genetics*
  • Deltaretrovirus / physiology
  • Genes, Viral*
  • Humans
  • Nucleic Acid Hybridization
  • RNA Splicing
  • RNA, Messenger / genetics
  • RNA, Viral / genetics*
  • T-Lymphocytes
  • Transcription, Genetic
  • Viral Proteins / genetics*

Substances

  • RNA, Messenger
  • RNA, Viral
  • Viral Proteins