1,2,5-thiadiazole 1-oxide and 1,1-dioxide derivatives. A new class of potent histamine H2-receptor antagonists

J Med Chem. 1982 Mar;25(3):210-2. doi: 10.1021/jm00345a003.
No abstract available

MeSH terms

  • Animals
  • Cimetidine / pharmacology
  • Dogs
  • Gastric Acid / metabolism
  • Guinea Pigs
  • Heart Rate / drug effects
  • Histamine H2 Antagonists / chemical synthesis*
  • In Vitro Techniques
  • Myocardial Contraction / drug effects
  • Rats
  • Structure-Activity Relationship
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / pharmacology

Substances

  • Histamine H2 Antagonists
  • Thiadiazoles
  • Cimetidine